Abstract

Objectives: To study clinical, subclinical features and to analyze treatment attitudes in patients with PROM. Materials and methods: A descriptive cross-sectional study, including 51 women with PROM at above 22 weeks’ gestation, from January 2020 to April 2021 at the Department of Obstetrics, Hue University of Medicine and Pharmacy Hospital. Results: Maternal mean age was 29.57 ± 5.38 years. The frequency of PROM in the primigravida (47.1%) was higher than the multigravida. Most patients were hospitalized without labour symptoms. There were insignificant differences in median white blood cell and amniotic fluid Index between < 37 and > 37 weeks group. The women that had cesarean in the < 37 and > 37 weeks group were 34.1% and 52.6%. There was a negative correlation between gestational age and duration time of PROM to delivery (r = 0.656; p = 0.000). The mean weight of gestation was 2634 ± 432 grams in the < 37 weeks group and 3152 ± 274 grams in > 37 weeks group. The sensitivities and specificities of level white blood cells (optimal cut-off was 10.59 x 109/L) for the diagnosis of chorioamnionitis were 90.2% and 52.5%. Chorioamnionitis was increased with the duration of PROM to delivery > 48 hours (OR 8.4, 95% CI 1.85 – 38.01, p = 0.007). Linear regression analysis did not show the correlation between these factors: gestational age, cesarean delivery, chorioamnionitis and neonatal infection. Neonatal respiratory distress syndrome was increased with chorioamnionitis (OR 14.0, 95% CI 1.1 – 178.9, p = 0.014). Conclusion: Gestation’s age and relevant factors are associated with treatment attitudes and outcomes in patients with PROM. More research is needed with a larger sample size to clarify the statistical significance of difference.