Abstract
Background: Chronic kidney disease-mineral and bone disorders (CKD-MBD) is characterised by generalised vascular calcification and impaired bone health. We aimed to investigate bone mineral density, vascular calcification in patients with non-dialysis chronic kidney disease (stages 3 - 5).
Materials and Methods: Descriptive cross-sectional study included 101 patients with CKD not receiving renal replacement therapy at the department of Nephrology and Rheumatology, Hue Central Hospital from April 2021 to June 2023. Bone mineral density (BMD) was measured using DEXA (Dual-energy X-ray Absorptionmetry). Abdominal aortic calcification was explored with a lateral abdominal radiograph machine and calculated on the Kauppila scale.
Results: Bone mineral density declines with age and in women are lower than in men. The proportion of osteoporosis at the lumbar spine, femoral neck, total hip were 53.5%, 7.9%, 21.8%, respectively. Or the osteopenia rate of the lumbar spine, femoral neck, total hip were 23.8%, 24.8%, 40.6%, respectively. The mean abdominal aortic calcification (AAC) score was 6.47±6.10 and 69.3% had AAC ≥1. BMD at 3 sites had a negative correlation with age. BMD of the lumbar spine had a positive correlation with the body mass index (BMI) (r=0.206). BMD of the total hip had a negative correlation with phosphorus level (r=-0.209), CaxP (r=-0.242), PTH (r=-0.231). AAC had a positive correlation with age (r=0.484), PTH (r=0.250) and had a negative correlation with BMD at 3 measurement locations.
Conclusion: The prevalence of osteoporosis and osteopenia, abdominal aortic calcification in patients with chronic renal disease is high. The osteoporosis and vascular calcification had the association with some clinical, subclinical factors in patients with non-dialysis chronic kidney disease (stages 3 - 5).
| Published | 2025-04-24 | |
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| Issue | Vol. 15 No. 1 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.1.8 | |
| Keywords | bệnh thận mạn, mật độ xương, loãng xương, canxi hóa động mạch chủ bụng chronic kidney disease, bone mineral density, osteoporosis, abdominal aortic calcification |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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