Tóm tắt
Background: Tinidazole (TNZ) demonstrates greater efficacy against anaerobic bacteria, particularly Gram-negative strains, compared to metronidazole. Nanosizing TNZ and incorporating it into in situ gel formulations for topical periodontitis treatment offers several advantages.
Objectives: This study aimed to formulate an in situ gel containing preformed Eudragit RSPO-based nanoparticles (NPs) of TNZ and to evaluate its physicochemical properties.
Materials and methods: Poloxamer 407 was used as a thermosensitive gelling agent, either alone or in combination with other gelling agents. The in situ gels containing TNZ NPs were prepared and evaluated for physicochemical properties.
Results: The in situ gel containing TNZ NPs, formulated with Poloxamer 407 and sodium alginate, exhibited a smooth texture, a gelation temperature of 31.33 ± 0.24 °C, a gelation time of less than one minute, a pH of 6.72 ± 0.03, and a stable gel state over an extended period. Compared to the in situ gel with TNZ material, the TNZ NP-loaded gel prolonged drug release. The drug release mechanism was best described by the Higuchi model (with F0).
Conclusion: This TNZ NP-loaded in situ gel formulation shows promise for further research in periodontitis treatment.
| Đã xuất bản | 09-05-2025 | |
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| Số tạp chí | Tập 15 Số 2 (2025) | |
| Phân mục | Nghiên cứu | |
| DOI | 10.34071/jmp.2025.2.25 | |
| Từ khóa | tinidazole, in situ gel, nanoparticle, poloxamer 407 |
công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .
Bản quyền (c) 2025 Tạp chí Y Dược Huế
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