Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Multidrug-resistant (MDR) bacterial infection is a serious global health problem, especially in Intensive Care Units (ICUs). The ICU-SEPSA score was developed to predict mortality in patients with MDR infections. Objective: To evaluate the prognostic value of the ICU-SEPSA score for predicting mortality among ICU patients with MDR bacterial infections at Hue Central Hospital. Methods: We conducted a prospective observational study of 108 patients with MDR bacterial infections admitted to the ICU from June 2024 to June 2025. ICU-SEPSA was recorded at the time the index culture was identified. Univariate logistic regression examined the association between ICU-SEPSA and mortality. Discrimination was evaluated using receiver operating characteristic (ROC) analysis to determine the optimal cut-off, area under the curve (AUC), sensitivity, and specificity. An exploratory combined model with the SOFA score was derived using logistic regression, yielding a linear predictor SOFA + 1.104 × ICU-SEPSA. Results: The overall mortality was 77.8%. The mean ICU-SEPSA score at the time of culture isolation was 7.0 ± 1.9. On univariate analysis, ICU-SEPSA predicted mortality (OR = 1.420; p < 0.001). At a cut-off value of 7.3, ICU-SEPSA demonstrated moderate discrimination (AUC = 0.686), with 56.0% sensitivity and 83.3% specificity. The exploratory combined model (SOFA + 1.104 × ICU-SEPSA) demonstrated better discrimination (AUC = 0.773); at a cut-off of 10.2, sensitivity was 95.2% and specificity 50.0%. Conclusions: The ICU-SEPSA score has prognostic value for mortality in ICU patients with MDR bacterial infections, and combining ICU-SEPSA with SOFA further improves predictive performance.
| Published | 2026-08-25 | |
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| Issue | Vol. 16 No. 04 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.4.1021 | |
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
Murray CJL, Ikuta KS, Sharara F, Swetschinski L, Robles Aguilar G, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022;399(10325):629-55.
World Health Organization: New report calls for urgent action to avert antimicrobial resistance crisis. https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis (2019).
O'Neill J. Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations. The Review on Antimicrobial Resistance; 2014.
Oh Y, Roh J, Lee J, Chung HS, Lee K, Lee MK. Sequential Organ Failure Assessment score as a predictor of mortality in ventilated patients with multidrug-resistant bacteremia. Acute and Critical Care. 2020;35(3):169-78.
Hariyanto H, Yahya CQ, Cucunawangsih C, Pertiwi CLP. Antimicrobial resistance and mortality. Afr J Infect Dis. 2022;16(2):13-20.
Chen Y-P, Tasi X-W, Chang K, Cao X-D, Chen J-R, Liao C-S. Multi-Drug Resistant Organisms Infection Impact on Patients Length of Stay in Respiratory Care Ward. Antibiotics. 2021;10(5):608.
Al-Hasan MN, Lahr BD, Eckel-Passow JE, Baddour LM. Predictive scoring model of mortality in Gram-negative bloodstream infection. Clinical Microbiology and Infection. 2013;19(10):948-54.
Sirichayanugul Taranee, Srisawat Chansinee, Thummakomut C, Prawang Abhisit, Huynh Nina S., Saokaew Surasak, et al. Development and internal validation of simplified predictive scoring (ICU-SEPSA score) for mortality in patients with multidrug resistant infection. Frontiers in Pharmacology. 2022;13.
Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection. 2012;18(3):268-81.
Delves PJ, Roitt IM. The Immune System. New England Journal of Medicine. 2000;343(1):37-49.
Yassin Ahmed, Eid RA, Mohammad MF, Elgendy MO, Mohammed Z, Abdelrahim MEA, et al. Microbial Multidrug-Resistant Organism (MDRO) Mapping of Intensive Care Unit Infections. Medicina. 2025;61(7):1220.
Dinh Phung Tran, Quang Dai Huynh, Thi Ngoc Thao Pham. Ventilator-associated pneumonia at Cho Ray Hospital. *Ho Chi Minh City Journal of Medicine (Supplement). 2016;20(1):91–95.
Wei Z, Zhou S, Zhang Y, Zheng L, Zhao L, Cui Y, et al. Microbiological characteristics and risk factors on prognosis associated with Acinetobacter baumannii bacteremia in general hospital: A single-center retrospective study. Frontiers in Microbiology. 2022;13.
Maia Marcelo De Oliveira, Da Silveira CDG, Gomes M, Fernandes SES, Bezerra De Santana R, De Oliveira DQ, et al. Multidrug-Resistant Bacteria on Critically Ill Patients with Sepsis at Hospital Admission: Risk Factors and Effects on Hospital Mortality. Infection and Drug Resistance. 2023;Volume 16:1693-704.