Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Coronary artery disease is one of the leading causes of mortality and disease burden worldwide. Recently, Apolipoprotein B, Apolipoprotein A1, and particularly the ApoB/ApoA1 ratio have been recognized as valuable indicators for cardiovascular risk assessment.
Objectives: To investigate the clinical and paraclinical characteristics, serum levels of Apolipoprotein B, Apolipoprotein A1, and the Apolipoprotein B/Apolipoprotein A1 ratio in patients with chronic coronary syndrome. Additionally, to evaluate the associations and correlations between serum Apolipoprotein B, Apolipoprotein A1, the Apolipoprotein B/Apolipoprotein A1 ratio, and the SYNTAX II score in patients with chronic coronary syndrome.
Materials and Methods: Patients presenting with chest pain and admitted to the Cardiovascular Center of Hue Central Hospital were enrolled and classified into two groups according to the 2021 ACC/AHA guidelines: the obstructive chronic coronary syndrome group and the non-obstructive chronic coronary syndrome group.
Results: The study conducted on 110 patients with chronic coronary syndrome (CCS), multivessel disease predominated, with a mean SYNTAX II score of 28.8 ± 9.44. Apo B, Apo A1, and notably the Apo B/Apo A1 ratio demonstrated significant value in predicting obstructive CCS. The Apo B/Apo A1 ratio yielded the highest diagnostic performance, with an optimal cut-off of 0.86 (AUC = 0.769, Se = 68.3%, Sp = 84.0%). Apo B correlated positively with total cholesterol, triglycerides, and non-HDL-C, whereas Apo A1 correlated positively with HDL-C and inversely with atherogenic lipids. As the SYNTAX II score increased, Apo B and the Apo B/Apo A1 ratio increased, while Apo A1 decreased. The strongest correlation with lesion severity and complexity was observed for the Apo B/Apo A1 ratio (r = 0.745, p < 0.01), clearly reflecting the severity and complexity of coronary artery lesions.
Conclusion: Apo B, Apo A1, and the Apo B/Apo A1 ratio demonstrated significant value in distinguishing patients with obstructive chronic coronary syndrome. Among them, the Apo B/Apo A1 ratio was the strongest indicator, clearly reflecting the severity and complexity of coronary artery lesions. These parameters were closely associated with the lipid profile and the SYNTAX II score. Their application may support more accurate risk stratification and guide more effective therapeutic decision-making.
| Published | 2026-08-25 | |
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| Issue | Vol. 16 No. 04 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.4.1100 | |
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Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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