Abstract

Background: Statin has been chosen to control LDL-C level and to prevent atherosclerosis. To evaluate effectiveness of statin, we conducted this research with 2 objectives: (1) Surveying characteristics of lipid profiles in outpatients with type 2 diabetes mellitus and coronary artery disease; (2) Evaluating results of statin therapy. Materials and methods: 74 patients enrolled were divided into two groups: prescribed statin with high and moderate intensity. Evaluating the lipid profiles and effectiveness of statin. Results: Hypertriglyceridemia decreased HDL-C, combination of hypertriglyceridemia and decreased HDL-C were the most popular in both groups. Moderate intensity statin therapy was administered for 44 patients (59.5%) even though they were stratified as extreme risk. The percentage of patients achieving LDL-C, non-HDL-C target with high intensity statin therapy are more than ones with moderate intensity statin (66.7% versus 9.1%; 76.7% versus 13.6%). Percentage of adverse effects related to muscle and liver are 2.7% and 2.7%. Conclusion: Hypertriglyceridemia decreased HDL-C, combination of hypertriglyceridemia and decreased HDL-C were the most popular in both groups. In practice, moderate intensity statin therapy was administered to patients who were stratified as extreme risk. The percentage of patients achieving LDL-C, non-HDL-C targets with high intensity statin therapy are more than ones with moderate intensity statin therapy. The percentage of adverse effects related to muscle and liver are low