Abstract

Background and objectives: Nowadays, herbal medicines continue to be a popular healthcare choice with the general public not only for health maintenance but also for enhancement of functions or processes. Therefore, studies on phytosomes are of interest. In recent times, Hue University of Medicine and Pharmacy has conducted on preparing curcumin phytosomes by different methods. Based on the obtained results and increased to apply phytosomes in clinical treatment, research will be conducted to apply curcumin phytosomes into capsule form.

Materials and methods: Curcumin, lecithin and other chemicals were utilized. Curcumin phytosome powder was prepared by solvent evaporation method with scale 500 g/batch followed by evaluation of the drug entrapment efficiency, mean particle size, and particle distribution index (PDI). Later, prepared powder was applied in hard capsules.

Results: The particle size of curcumin phytosomes was in the narrow range of 300 - 450 nm with PDI < 0.4, the absolute value of zeta potential was higher than 30 mV. The optimal formula of curcumin phytosome capsules containing 50mg active ingredient had the release rate curcumin from capsules was higher than 94%.

Conclusion: Capsules containing curcumin phytosome were successful prepared