Abstract
Background: Treatment of diabetes mellitus with metformin in long duration may be associated with vitamin B12 deficiency and/or hyperhomocysteinemia.
Objective: The aims of this study were to determine the serum vitamin B12 and homocysteine concentrations in patients with type 2 diabetes treated with metformin and to examine the association between vitamin B12 deficiency and/or hyperhomocysteinemia with the dose and duration of treatment with metformin in patients with type 2 diabetes.
Methods: Cross sectional study.
Results: A total of 114 patients with type 2 diabetes were studied. The average age was 51.1 ± 6.2, and 55.3% were female. The average serum vitamin B12 concentration in the disease group was 458 ± 211 pg/mL, lower than that in the control group (647 ± 191 pg/mL), p<0.05. The average serum homocysteine concentration in the disease group was 12.5 ± 4.3 μmol/L, higher than that in the control group (9.02 ± 2.37 μmol/L), p<0.05. 17.8% of patients treated with metformin have vitamin B12 deficiency 21.9% of patients treated with metformin have hyperhomocysteinemia, and 13.7% of patients have both vitamin B12 deficiency and hyperhomocysteinemia. There was no significant correlation between vitamin B12 deficiency and/or hyperhomocysteinemia with metformin dose (p=0.99). There was a significant correlation between vitamin B12 deficiency and/or hyperhomocysteinemia with metformin treatment duration ≥ 5 years (p<0.001).
Conclusion: The average serum vitamin B12 concentration in the disease group was lower than that in the control group, and the average serum homocysteine concentration in the disease group was higher than that in the control group: 17.8% patients have vitamin B12 deficiency, 21.9% patients have hyperhomocysteinemia, 13.7% patients have both vitamin B12 deficiency and hyperhomocysteinemia. There was no significant correlation between vitamin B12 deficiency and/or hyperhomocysteinemia with metformin dose. There was a significant correlation between vitamin B12 deficiency and/or hyperhomocysteinemia with metformin treatment duration ≥5 years.
| Published | 2025-04-24 | |
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| Issue | Vol. 15 No. 1 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.1.17 | |
| Keywords | Metformin, đái tháo đường típ 2, thiếu vitamin B12, tăng homocysteine Metformin, type 2 diabetes, vitamin B12 deficiency, hyperhomocysteinemia |
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