Abstract
Background: Vancomycin is an antibiotic with a narrow therapeutic range and needs to be used appropriately to achieve effectiveness and minimize toxicity. Therefore, this study was conducted with the aim of analyzing the current use of vancomycin to enhance its effectiveness at Thanh Thuy District Medical Center.
Materials and methods: Retrospective descriptive study based on data obtained from medical records of adult inpatients (≥ 18 years old) at Thanh Thuy District Medical Center during the period from 01/01/2022 to 31/12/2023 treated with vancomycin intravenously for at least 48 hours.
Results: The median age of 83 patients was 65 years old, men accounted for 74.7%. Patients discharged from the hospital with recovery/improvement accounted for 85.5%. Vancomycin was prescribed empirically in 97.6% of patients. 3,6% of patients were subjected to microbiological culture, of the 2 specimens with positive results, there was 1 patient diagnosed with Staphylococcus aureus. Loading dose regimen was applied in 27.7% of patients while the common maintenance dose was 1 g/24 h (at 70.4%). The percentage of patients experiencing nephrotoxicity was 14.5%.
Conclusion: The study identified a significant proportion of patients who were not administered appropriate loading and maintenance doses based on their renal function. This highlights the need for Thanh Thuy District Medical Center to enhance clinical pharmacists’ support for physicians by developing clear guidelines and implementing blood level monitoring of vancomycin, ultimately promoting individualized treatment approaches.
| Published | 2025-09-30 | |
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| Issue | Vol. 15 No. 5 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.5.8 | |
| Keywords | Vancomycin, liều duy trì, liều nạp, MRSA, độc tính trên thận Vancomycin, maintenance dose, loading dose, MRSA, nephrotoxicity |
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