Abstract
Background: The application of green solvents in the extraction of bioactive compounds from medicinal plants has become a prominent approach in the development of sustainable extraction processes.
Objectives: In this study, a sustainable extraction strategy for triterpenoids from Ligustrum lucidum is developed, employing hydrophobic deep eutectic solvents in combination with macroporous resins under ultrasound-assisted extraction.
Materials and method: Hydrophobic deep eutectic solvents based on menthol and lauric acid were initially screened. Extraction conditions were optimized using response surface methodology. Triterpenoids were recovered from the extract using a solid–liquid extraction approach with macroporous resins. The reusability of the initial materials was also evaluated.
Results: The lauric acid–valeric acid exhibited the highest extraction eficiency for triterpenoids. Under optimal conditions, the extraction yield reached 15.17 mg/g. The macroporous resin HPD-300 successfully recovered 98.91% of triterpenoids from the extract, yielding a product containing 53.95% triterpenoids. Both the solvent and the resin were effectively reused over three consecutive extraction and recovery cycles.
Conclusion: These findings contribute to a better understanding of green extraction processes for triterpenoids from Ligustrum lucidum, aiming to replace hazardous organic solvents with safer and more environmentally friendly green solvents
| Published | 2025-09-30 | |
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| Issue | Vol. 15 No. 5 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.5.17 | |
| Keywords | triterpenoid, Nữ trinh tử, chiết xuất xanh, dung môi eutectic sâu kỵ nước triterpenoid, Ligustrum lucidum, green extract, hydrophobic deep eutectic solvents |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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