Tóm tắt
Objective: This study aimed to validate the diagnostic utility of the Rajavithi-Ovarian Cancer Predictive Score (R-OPS) in preoperative ovarian cancer diagnosis and compare its efficacy with that of the Risk of Ovarian Malignancy Algorithm (ROMA).
Methods: A prospective cohort study was conducted at two hospitals in Vietnam from January 2024 to January 2025, involving 215 patients with adnexal masses (69 malignant, 146 benign) who underwent surgery. R-OPS was calculated using menopausal status, ultrasound findings, and serum cancer antigen 125 (CA125) and human epididymal protein 4 (HE4) levels.
Results: R-OPS achieved an AUC of 91.4% (95% CI: 87.0 - 95.7%). At a cut-off of > 330, it displayed a specificity of 95.2% and a sensitivity of 71.0%, with positive and negative predictive values of 86.0% and 87.3%. R-OPS outperformed ROMA by 5.9% in AUC (P<0.001).
Conclusion: R-OPS is an effective tool for preoperative differentiation between benign and malignant ovarian masses, demonstrating superior performance compared to ROMA.
| Đã xuất bản | 09-05-2025 | |
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| Số tạp chí | Tập 15 Số 2 (2025) | |
| Phân mục | Nghiên cứu | |
| DOI | 10.34071/jmp.2025.2.15 | |
| Từ khóa | Ovarian cancer, R-OPS, ROMA, diagnostic accuracy, predictive score, biomarkers |
công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .
Bản quyền (c) 2025 Tạp chí Y Dược Huế
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