Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Tóm tắt
Background: A high-performance liquid chromatography method with photodiode-array detection (HPLC-PDA) was developed and validated for the simultaneous quantification of caffeine (CAF), furosemide (FUR), phenolphthalein (PHE), and sibutramine (SIB) in herbal weight-loss products.
Materials and Methods: The method employed methanol for sample extraction and utilized a C18 column with a phosphate buffer-acetonitrile gradient.
Results: Validation according to ICH and AOAC guidelines confirmed excellent linearity (10-150 µg mL⁻¹, R² ≥ 0.991), accuracy (spike recovery: 95.89-103.08 %), and precision (intra- and inter-day RSD ≤ 2.66 %). The limits of detection and quantification were sufficiently low to detect these adulterants at trace levels. Application to 32 commercial products from Vietnam revealed that 28.1 % (9 samples) were adulterated with four synthetic drugs, primarily with SIB alone or in combination with PHE.
Conclusion: These findings underscore the need for enhanced regulatory oversight of the weight-loss supplement market. Thus, this method represents a robust, sustainable, and readily applicable solution for quality control laboratories.
| Đã xuất bản | 25-08-2026 | |
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| Số tạp chí | Tập 16 Số 04 (2026) | |
| Phân mục | Nghiên cứu | |
| DOI | 10.34071/jmp.2026.4.966 | |
| Từ khóa | sibutramine; phenolphthalein; furosemide; caffeine; HPLC; adulteration; weight-loss products |
công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .
Bản quyền (c) 2026 Tạp chí Y Dược Huế
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