Abstract

Background: Knowledge about premature coronary artery disease (PCAD) is still limited in Vietnam. This study aimed to describe status of coronary artery lesion and its associated risk factors in these patients. Methods: A cross sectional study (2018 - 2019) of 177 patients aged ≤ 55 years for men and ≤ 60 for women undergoing coronary angiography was conducted. Results: Most of PCAD patients was acute coronary syndrome (83.1%). The most common cardiovascular risk factor was smoking (63.3%). Complex lesions were common in PCAD patients, including long lesion, (44.6%), diffuse lesion (18.6%), chronic total occlusion (12.4%), bifurcation lesion (12.4%), ostial lesion (5.6%) and SYNTAX score ≥ 22 (27.9%). Multivariate logistic regression analysis showed that serum low density lipoprotein cholesterol (LDL-C) level was independently related to the presence of moderate-severe coronary artery disease (SYNTAX score ≥ 22) with Odds ratio as 1.706. Conclusions: PCAD patients had significant rates of complex lesions. Elevated serum LDL-C level was independent risk factor related to mordeate-severe coronary artery disease in these patients.