Abstract
Objective: Bone grafting is a widely utilized surgical procedure for the treatment of various conditions, including non-union fractures, segmental bone loss, and bone defects following tumor excision. In tissue banks, allogeneic fresh bone is processed through specific protocols to ensure ease of preservation, sterility, and reduced immunogenicity. The fresh bone preserved by deep-freezing is used as a conductive material for bone formation, retaining its material properties and remaining usable after thawing. This study aims to provide a preliminary evaluation on the utilization of allogeneic bone grafts in the treatment of several orthopedic traumas at Hue University of Medicine and Pharmacy Hospital.
Subjects and methods: A retrospective study was conducted, collecting medical records of all patients indicated for fresh allogeneic bone grafting from January 2019 to December 2023 at Hue University of Medicine and Pharmacy Hospital. The study variables included: age, gender, number of patients, preoperative diagnosis for bone grafting, graft site, and number of graft units used.
Results: A total of 125 patients participated in the study, with males comprising 56.8% and females comprising 43.2%. The average age of the patients was 47.17 ± 19.39, with the youngest patients were six and the oldest patients were 86. The age group receiving allogeneic fresh bone grafts most frequently was over 60, accounting for 34.4%. The age group of 20 to <40 represented 30.4%, while those under 20 accounted for 7.2%. Approximately 88.8% of patients received one graft unit, 8% of patients received two units, and only 3.2% of cases received three or four units. Bone defects were the most common indication for grafting (58.4%). The rates for hip joint replacement, spinal disorders, and non-union fractures were 28%, 7.2%, and 6.4%, respectively. The injuries in the femur, tibia, and hip joint indicated for grafting were 30.4%, 21.6%, and 12%, respectively. In addition, other sites such as the humerus, spine, clavicle, knee joint, and foot bones also had indications for grafting allogeneic fresh bone after deep-freezing storage at lower rates.
Conclusion: Allogeneic fresh frozen bone represents a potential graft material source in orthopedic trauma surgeries. Allogeneic fresh bone grafting has been utilized widely among all age groups for treating bone defects, non-union fractures, spinal conditions, and more.
| Published | 2025-05-06 | |
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| Issue | Vol. 15 No. 1 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.1.27 | |
| Keywords | khuyết xương, xương tươi đồng loại, ghép xương bone defect, allogeneic fresh bone, bone grafting |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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