Abstract
Objective: To identify some clinical characteristics, histopathological features, and immunophenotypes of diffuse large B-cell lymphoma in the gastrointestinal tract.
Subjects and Methods: 99 patients were diagnosed with gastrointestinal Diffuse large B-cell lymphoma at K Hospital (Hanoi), Hue Central Hospital, and Hue University of Medicine and Pharmacy Hospital from January 2021 to June 2023.
Results: The average age was 55 ± 16 years, with a male/female ratio of 1.15. The complication rate was 21.2%, and the rate of B symptoms was 15.2%. 30.3% were diagnosed at stages IIE and IV. Histopathologically, the diffuse morphology accounted for 100%, with large tumor cells (77.8%), and a mixture of centroblasts and immunoblasts accounting for 72.7%. 86% of the germinal-centre B-cell subtype had CD10 positivity, while the activated B-cell subtype had 45% Bcl6 negativity and 45% Bcl6, MUM1 positivity. There was no significant difference in tumor location, complication rate, B symptoms rate, and stage between the activated B-cell and germinal-centre B-cell subtype of diffuse large B-cell lymphoma.
Conclusion: Diffuse large B-cell lymphoma often presents with non-specific symptoms. Histopathologically characterized by diffuse morphology of large cells, partly a mixture of centroblasts and immunoblasts, four immunophenotypes. There is an overlap in some clinical characteristics between the activated B-cell and germinal-centre B-cell subtype.
| Published | 2025-06-25 | |
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| Issue | Vol. 15 No. 3 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.3.13 | |
| Keywords | triệu chứng B, dưới típ hoạt hóa, dưới típ tâm mầm B symptoms, activated B-cell DLBCL, germinal-centre B-cell DLBCL |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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