Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Currently, the incidence of chronic kidney disease (CKD) is increasing, and causing a great burden on the health system. Serum galectin-3 is one of the new biomarkers that helps diagnose and predict chronic kidney disease. Increased galectin-3 concentration is associated with renal fibrosis, the risk of rapid renal function decline, new chronic kidney disease and progressive renal failure, as well as cardiovascular events. Vascular calcification is a cardiovascular risk factor typical of chronic kidney disease.
Objectives: Survey the value of serum galectin-3 concentration in patients with chronic kidney disease stages; Evaluate the relationship between serum galectin-3 and vascular calcification in study patients.
Subjects and methods: cross-sectional descriptive study, on 172 CKD patients at Hue Central Hospital from October 2024 to August 2025. Serum galectin-3 was performed by chemiluminescent microparticle immunoassay on the Alitiny machine at the Department of Biochemistry - Hue Central Hospital.
Results: The average serum galectin-3 concentration was 53.97 ± 25.68 ng/mL, increasing gradually from 28.87 ± 8.02 ng/mL (G3), 44.77 ± 17.07 ng/mL (G4), 56.69 ± 20.66 ng/mL (G5) and 72.75 ± 24.86 ng/mL (HD). Carotid artery calcification occurred in 47.1%. Serum galectin-3 was weakly positively correlated with the degree of carotid artery calcification (r = 0.212), but no correlation with carotid IMT was found.
Conclusion: There was a significant increase in serum galectin-3 concentration in chronic kidney disease, and there was a correlation between serum galectin-3 and aortic calcification.
| Published | 2026-06-28 | |
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| Issue | Vol. 16 No. 3 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.3.802 | |
| Keywords | galectin-3, chronic kidney disease, vascular calcification in CKD galectin-3, bệnh thận mạn, vôi hóa mạch máu |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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